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Choosing between Nexgard Plus and Simparica Trio can be confusing for pet owners.

Both products offer protection against common parasites like fleas and ticks (and we know fleas are bad this year), but their specific benefits differ.

In this article, I’m going tonna compare Nexgard Plus vs Simparica Trio to help you choose the best products for keeping your pet tick and flea-free.

I’ll dive into some technical stuff I recently talked about with our in-house vet and check out their ingredients, effectiveness, and suitability for different dogs.

My aim? By the end of the article, you’ll know which treatment is perfect for your pet’s needs and you’ll feel sure you’re doing everything you can to keep your furry friend healthy.

Overview of Nexgard Plus and Simparica Trio

Simparica Trio Vs NexGard Plus

Nexgard Plus and Simparica Trio are like, two super popular treatments for dogs that help with parasites.

They both do an awesome job protecting against fleas, ticks, and heartworms, but they have different ingredients and also take care of other parasites too.

Also, don’t forget that these two aren’t the only options available. If you wanna know more, we’ve tested all the best dog tick and flea collars out there!

Key Ingredients and Action

Nexgard Plus and Simparica Trio have different ingredients to fight against parasites.

Nexgard Plus has afoxolaner, moxidectin, and pyrantel, while Simparica Trio has sarolaner, moxidectin, and pyrantel.

These ingredients work together to protect your dog from fleas, ticks, heartworm disease, roundworms, and hookworms.

Both products provide broad protection, but Simparica Trio is better at preventing Lyme disease and treating Gulf Coast ticks.

Nexgard Plus is also effective against another type of hookworm called Ancylostoma braziliense.

Approved Age for Usage and Dosage Forms

Nexgard Plus and Simparica Trio are both approved for dogs and puppies aged 8 weeks and up.

The minimum weight requirement is kind of different: Nexgard Plus is good for dogs weighing 4 lbs or more, while Simparica Trio can be used on dogs as light as 2.8 lbs.

Both treatments come in chewable tablets that you give to your dog once a month.

Nexgard Plus tastes like beef, while Simparica Trio has a liver flavor that makes it even more yummy for your furry friend.

Comparative Analysis

Nexgard Plus and Simparica Trio have some advantages when it comes to protecting against fleas, ticks, and heartworms.

You’ll notice some important differences in how effective they are against certain parasites and what other pests they can cover.

Efficacy Against Fleas, Ticks, and Heartworms

Both Nexgard Plus and Simparica Trio effectively combat common pet parasites. Here’s a comparison of their efficacy:

ParasiteNexgard PlusSimparica Trio
FleasKills in 4 hoursKills in 3 hours
TicksKills in 24 hoursKills in 8 hours
HeartwormsPrevents for 1 monthPrevents for 1 month
Gulf Coast TicksNot effectiveTreats effectively
Lyme DiseaseDoes not preventPrevents

Simparica Trio acts faster against fleas and ticks. It offers additional protection against Gulf Coast ticks and Lyme disease. 

Both treatments prevent heartworm disease for one month. You’ll find these FDA-approved products safe for your pet when used as directed.

Additional Protection Against Other Parasites

Beyond flea, tick, and heartworm protection, these treatments offer additional parasite defense for your pet during travels.

Nexgard PlusSimparica Trio
• Targets Ancylostoma caninum
• Eliminates Ancylostoma braziliense
• Protects against Uncinaria stenocephala
• Targets Ancylostoma caninum
• Eliminates adult Uncinaria stenocephala
• Guards against Gulf Coast ticks
• Aids in Lyme disease prevention

Nexgard Plus provides broader hookworm protection. Simparica Trio offers unique Gulf Coast tick defense .

 Your travel destination influences the ideal choice for your pet’s parasite protection.

Pros and Cons of Each Treatment

Nexgard Plus and Simparica Trio have their own pros and cons for different dogs.

You will need to consider stuff like your dog’s size, breed, and the particular parasites they might be up against to figure out which one is the best choice.

Suitability for Different Dog Sizes and Breeds

Why do vets recommend Simparica Trio

Nexgard Plus and Simparica Trio offer protection for dogs of different sizes and breeds.

They work for a wide range of dogs, so you can be sure your travel buddy is well-protected against parasites.

  • Perfect for puppies: Both products are safe to use on puppies as young as 8 weeks old.
  • Weight requirements: Nexgard Plus is suitable for dogs weighing at least 4 lbs, while Simparica Trio can be used on dogs as light as 2.8 lbs.
  • Great for all breeds: These treatments are effective for all types of dogs, from small Chihuahuas to big Great Danes.
  • Dosing based on size: Both products have different dosage options based on your dog’s weight, so you can give them the right amount for safe and effective prevention.
  • Easy for travel: The chewable form of both treatments makes them convenient to bring and give to your dog while you’re on the go.
  • Protection against multiple parasites: Whether your dog is big or small, both products protect against fleas, ticks, and heartworms.
  • Appealing to different tastes: Nexgard Plus has a beef flavor, and Simparica Trio has a liver flavor, so most dogs find them tasty.
  • Great for active dogs: Both treatments provide long-lasting protection that’s suitable for active breeds and working dogs.

Flavor and Palatability

Nexgard Plus and Simparica Trio have yummy flavors that make it easier for pet owners to give them to their pets. Nexgard Plus has a beef flavor, and Simparica Trio has a liver flavor.

Both treatments are loved by dogs, with Nexgard Plus having a 96.3% acceptance rate and Simparica Trio at 91.9%.

These chewable tablets taste great, so you can be sure your dog gets the full dose and stays protected during your travels.

So, Which is better, NexGard Plus or Simparica?

Choosing between Nexgard Plus and Simparica Trio really depends on what your dog needs.

Nexgard Plus is a perfect cheaper alternative to Simparica Trio, as both of these treatments work great in fighting off fleas, ticks, and heartworms.

Simparica Trio is often recommended by vets because it goes the extra mile by providing protection against Lyme disease and Gulf Coast ticks. That’s why, personally, I’d consider Simparica a must-have in our list of dog camping essentials.

To make sure you’re making the right decision, it’s always a good idea to talk to your vet.They’ll be able to figure out what’s best for your pet’s health and lifestyle.

Just make sure to give the chosen treatment regularly to keep those pesky parasites at bay.

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